Final Project Report, Diesel And Metal Particulates On Interferon Synthesis.
The effects of diesel and metal particulates on interferon synthesis were studied in-vitro. Cultured Rhesus-monkey cell monolayers were treated with copper (7440508), aluminum (7429905), or nickel (7440020) particulates. Particulate concentrations, particle size, and duration of treatment were not specified. Cultures were assayed for viral induction of interferon. Cultured cell monolayers were treated with diesel engine emission particulates and assayed for viral induction of interferon. Cultures of cell monolayers were pretreated with 50 milligrams of a nonionic polymer, then exposed to diesel particulates, or diesel particulates were pretreated and then used to treat monolayers. Cultures were assayed for viral induction of interferon. Diesel emission particulates were pretreated and then used to treat cell monolayer cultures, the cultures then being assayed for interferon production. Metal particulates reduced the amount of interferon synthesis, the effect being greatest with copper. Diesel emission particulates reduced interferon production by approximately 60 percent. Pretreatment of cell cultures eliminated the effects of the particulates on interferon synthesis.
NIOSH-Author; Aerosol-particles; Airborne-particles; Bioassays; Biological-effects; Comparative-toxicology; Metal-dusts; Medical-research; Diesel-exhausts;
7440-50-8; 7429-90-5; 7440-02-0;
NTIS Accession No.
NIOSH, U.S. Department of Health, Education, and Welfare, Project No. VKC-R21-149, 5 pages