NIOSHTIC-2 Publications Search

In vitro tests for workplace cocarcinogens.

Authors
Sabharwal PS; Gulati DK; Russell S
Source
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Contract 200-82-2544, 1984 May; :1-199
Link
NIOSHTIC No.
00134779
Abstract
In-vitro assays of workplace cocarcinogens were conducted. Compounds selected by NIOSH were evaluated for their ability to block metabolic cooperation between wild type and mutant Chinese-V-79- hamster cells. The concentrations of the compounds ranged from 0.01 to 25000 micrograms per milliliter. The inhibition of metabolic cooperation was evaluated by determining the number of surviving mutant cells. Mezerein (34807415), 12-o-tetradecanoylphorbol-13- acetate (544638), amobarbital (57432), butylated-hydroxytoluene (128370), phenobarbital (50066), butylated-hydroxyanisole (25013165), tryptophan (153946), and catechol (120809) inhibited metabolic cooperation between the wild type and mutant cells. Sodium-cyclamate (139059), 2,4-dinitrofluorobenzene (70348), benzoyl- peroxide (94360), phorbol (17673255), n-dodecane (112403), tert- butyl-hydroperoxide (75912), hydrogen-peroxide (7722841), and ethyl- phenylpropiolate (2216946) had no significant effect on metabolic cooperation. The overall response from the remaining compounds sodium-saccharin (128449), 1-phenyldodecane (123013), pyrogallol (87661), phenol (108952), and sucrose (57501) was either ambiguous or weakly positive. Tert-butyl-hydroperoxide and n-dodecane enhanced metabolic cooperation. The observed response of sucrose may represent changes in the osmolarity of the culture medium. Of the compounds tested, 15 have been accurately assessed for their ability to block metabolic cooperation.
Keywords
NIOSH-Contract; Carcinogenicity; In-vitro-studies; Clinical-chemistry; Animal-studies; Bioassays; Chemical-properties; Biological-effects; Biochemical-tests; Metabolic-study
CAS No.
34807-41-5; 544-63-8; 57-43-2; 128-37-0; 50-06-6; 25013-16-5; 153-94-6; 120-80-9; 139-05-9; 70-34-8; 94-36-0; 17673-25-5; 112-40-3; 75-91-2; 7722-84-1; 2216-94-6; 128-44-9; 123-01-3; 87-66-1; 108-95-2; 57-50-1
Publication Date
19840530
Document Type
Final Contract Report
Funding Type
Contract
Fiscal Year
1984
Identifying No.
Contract-200-82-2544
NIOSH Division
DBBS
Source Name
National Institute for Occupational Safety and Health
State
OH
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division