Effects Of Perchloroethylene/Drug Interaction On Behavior And Neurological Function.
Stewart-RD; Hake-CL; Wu-A; Kalbfleisch-J; Newton-PE; Marlow-SK; Vucicevic-Salama-M
Public Health Service, U.S. Department of Health, Education, and Welfare, Cincinnati, Ohio, NTIS PB83-174-607 1977 Apr:145 pages
Behavior and neurological functions were evaluated in persons exposed to perchloroethylene (127184) following intake of alcohol (64175) and a depressant drug. Six volunteers of each sex were chosen and subjected to a thorough physical examination. The experimental procedure consisted of perchloroethylene exposure in controlled environment chamber with continuous health monitoring. Alcohol in the form of 100 proof vodka and a mild depressant diazepam (439145) were added, one at a time, to PCE vapors. Exposure was 0.25, or 100 parts per million (ppm) of PCE; 0, 6, or 10 milligram per day diazepam; and 0.0, 0.75, 001.5 milliliter vodka per kilogram. Exposures were replicated and testing was done in a double blind mode. Neurological tests included eye hand coordination, rotary pursuit, coordination, eye velocity, and dual attention tasks. Electrocardiograms and mood evaluation tests were also administered. Data showed that subjects exhibited decrement in performance of at least one test with each drug. No interaction with perchloroethylene was demonstrated. While alcohol affected eye hand coordination, rotary pursuit and coordination tests, diazepam had subtle effects and a significant effect on rotary pursuit test only. The authors conclude that the hazard of low doses of alcohol or diazepam added to perchloroethylene exposure is no greater than that attributable to alcohol or diazepam alone.
NIOSH-Contract; Safety-research; Biochemical-analysis; Biological-monitoring; Physiological-testing; Dose-response; Drugs; Psychological-effects; Contract-201-75-0059;
127-18-4; 64-17-5; 439-14-5;
NTIS Accession No.
Public Health Service, U.S. Department of Health, Education, and Welfare, Cincinnati, Ohio, NTIS PB83-174-607