The reproductive effects of nine chemicals were assessed in CD-1- mice. The maximum tolerated dose (MTD) was determined for each of the chemicals. Test substances used were: ethylene-thiourea (96457), 200 milligrams per kilogram (mg/kg); ethylene-diamine (107153), 400mg/kg; sodium-selenite (10102188), 14mg/kg; ethylene- glycol (107211), 11090mg/kg; diethylene-glycol (111466), 11180mg/kg; benzyl-alcohol (100516), 750mg/kg; trimellitic anhydride (552307), 550mg/kg; nitrofurazone (59870), 100mg/kg; and diethylene-glycol- (dibutyl-ether) (111466), 2000mg/kg. Pathogen free sperm plug positive females received the MTD of each chemical throughout days 7 to 14 of gestation. Animals were allowed to deliver litters and nurse for 3 days. The number of pups in each litter and total litter weights were recorded on day 1 and after 48 hours. Reproductive, gestational, and viability indices were calculated, as was maternal weight change during treatment and pregnancy. Severity of effects on pups correlated with the toxicity to the dam. No reproductive effects were observed for ethylene-thiourea and trimetallic-anhydride. A reproductive hazard was suspected for ethylene-diamine, benzyl-alcohol, nitrofurazone, diethylene-glycol, and diethylene-glycol-(dibutyl-ether). Substantial reproductive hazard was predicted for sodium-selenite and ethylene-glycol.
We take your privacy seriously. You can review and change the way we collect information below.
These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance.
Cookies used to make website functionality more relevant to you. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests.
Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data.
Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. These cookies may also be used for advertising purposes by these third parties.