The reproductive effects of nine chemicals were assessed in CD-1- mice. The maximum tolerated dose (MTD) was determined for each of the chemicals. Test substances used were: ethylene-thiourea (96457), 200 milligrams per kilogram (mg/kg); ethylene-diamine (107153), 400mg/kg; sodium-selenite (10102188), 14mg/kg; ethylene- glycol (107211), 11090mg/kg; diethylene-glycol (111466), 11180mg/kg; benzyl-alcohol (100516), 750mg/kg; trimellitic anhydride (552307), 550mg/kg; nitrofurazone (59870), 100mg/kg; and diethylene-glycol- (dibutyl-ether) (111466), 2000mg/kg. Pathogen free sperm plug positive females received the MTD of each chemical throughout days 7 to 14 of gestation. Animals were allowed to deliver litters and nurse for 3 days. The number of pups in each litter and total litter weights were recorded on day 1 and after 48 hours. Reproductive, gestational, and viability indices were calculated, as was maternal weight change during treatment and pregnancy. Severity of effects on pups correlated with the toxicity to the dam. No reproductive effects were observed for ethylene-thiourea and trimetallic-anhydride. A reproductive hazard was suspected for ethylene-diamine, benzyl-alcohol, nitrofurazone, diethylene-glycol, and diethylene-glycol-(dibutyl-ether). Substantial reproductive hazard was predicted for sodium-selenite and ethylene-glycol.
NIOSH, Public Health Service, U.S. Department of Health, Education, and Welfare, Cincinnati, Ohio, NTIS PB83-258-616