Immunological Parameters Of Coal Workers' Pneumoconiosis: Final Report.
NIOSH 1978 Aug:78 pages
An immunological and immunogenetic investigation of coal worker's pneumoconiosis (CWP) was conducted. Four geographic regions of study were established, depending on the type of coal mined in the region. Blood samples were taken from 358 workers with no disease, simple CWP, or complicated CWP. Samples were tested for histocompatability, blood type, antisera, passive hemagglutination, and antinuclear antibodies. There were no significant differences in the distribution of human leukocyte antigen (HLA) between the segments representing each geographic region. The frequency of the HLA-A-1 antigen was significantly greater in the no disease category than in CWP categories. No other significant differences in HLA antigens were noted. Marked regional differences occurred for ABO system and MN system antigens; group A was significantly lower in the central region and group AB was increased. The southern region showed a decreased frequency of Gm phenotype. No significant differences in disease categories were noted between regions. The authors conclude that there is a significant negative association between HLA-A-1 antigen and CWP. Ethnic differences are reflected in blood group antigens. No significant differences in other immunological parameters are seen.
NIOSH-Author; Morgantown-Technical-Report; Coal-mining; Disease-incidence; Immunologic-disorders; Genetic-factors; Immunology; Disease-prevention;
NTIS Accession No.
Appalachian Laboratory for Occupational Safety and Health, NIOSH, Morgantown, West Virginia, 78 pages, 82 references