The reproductive toxicity of nine chemicals was evaluated. Pregnant CD-1-mice were treated daily by gavage on days 7 to 14 of gestation with one of the following chemicals: 3.5 milligrams per kilogram (mg/kg) of sodium-selenite (10102188), 100mg/kg of ethylene-thiourea (96457), 500mg/kg of 2-(2-butoxyethoxy)ethanol (112345) (2-BEE), 2955mg/kg of ethylene-glycol-diethyl-ether (629141) (EGDE), 5500mg/kg of diethylene-glycol-monoethyl-ether (111900) (DGME), 11270mg/kg of triethylene-glycol (112276) (TEG), 560mg/kg of aniline (62533), 1200mg/kg of p-nitroaniline (100016), or 365mg/kg of N,N- dimethyl-aniline (121697) (DMA). Maternal body weights, mortality and toxic symptoms were recorded. Litter size, litter weight, pup weight, and offspring viability were determined. Dams and pups were killed on day 4 postpartum for autopsy. No adverse effects were found for sodium-selenite, ethylene-thiourea, 2-BEE, TGE, or DMA. EGDE caused increased numbers of dead and resorbed litters, reduced pup weight, and reduced offspring viability. DGME was slightly toxic, but did not adversely affect reproductive outcome. Aniline significantly reduced offspring viability. With p-nitroaniline, maternal survival was reduced, maternal weight gain was decreased, the number of dead and resorbed litters was increased, and offspring viability was reduced.
Experimental Toxicology Branch, Division of Biomedical and Behavioral Science, NIOSH, PB83-257-600