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Occupational exposure to cancer chemotherapeutic agents in pharmacists and nurses.
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, IWS 80-41, 1983 Oct; :1-:51
The presence of mutagenic substances in the urine of health workers who handle chemotherapeutic agents was examined. Urine samples were obtained from 21 workers, 19 of whom had handled chemotherapy drugs within 72 hours, and 17 of whom had handled the agents on the day of urine collection. Samples were also collected from a nonexposed comparison group. Urine samples were pooled and analyzed for mutagenic activity in TA-98 and TA-100 Salmonella-typhimurium strains. Analysis of variance was used to detect differences in revertant colonies. Rat liver S-9 fractions were used in some cultures. No significant differences were seen between job categories or between exposed and nonexposed subjects for number of revertant colonies, age, total years worked, or amount of creatinine. Smokers had significant increases in revertants. No direct toxicity was seen. The author concludes that exposures to chemotherapeutic agents be minimized under all circumstances. The use of laminar flow hoods or laminar flow cabinets and the maintenance of aseptic conditions during drug preparation and handling are recommended for the protection of the worker and employee.
NIOSH-Author; NIOSH-Survey; Field-study; Nursing; Occupational-hazards; Toxic-effects; Safety-practices; Urinalysis; Safety-equipment; Biochemical-analysis
Field Studies; Industry Wide
NTIS Accession No.
National Institute for Occupational Safety and Health
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Content source: National Institute for Occupational Safety and Health Education and Information Division