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Health hazard evaluation report: HETA-81-304-1361, Robertson Paper Box Company, Monteville, Connecticut.

Authors
Cullen-M; McManus-K
Source
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, HETA 81-304-1361, 1983 Aug; :1-16
NIOSHTIC No.
00133416
Abstract
Environmental samples were analyzed for dipropylene-glycol- monomethyl-ether (20324327) (DGME) at Robertson Paper Box Company (SIC-2752) Monteville, Connecticut in October 1981. The survey was requested on behalf of approximately 500 workers because of a possible relationship between a fatal case of aplastic anemia and exposure to DGME. Personal breathing zone and general work area air samples were taken from around printing presses. Samples were analyzed for DGME using gas chromatography. Medical studies were performed on seven males who had worked on the five color press. Health and exposure questionnaires were completed. Peripheral blood examinations and physical examinations focusing on reticuloendothelial organs were performed. Bone marrow from the posterior superior iliac crest was examined. Concentrations of DGME in air samples ranged from 3.6 to 39.0 milligrams per cubic meter (mg/m3). This was below the OSHA standard of 600mg/m3. Blood and physical examinations revealed no abnormality. Aspirates and cytogenic evaluation of cultured cells of bone marrow were all normal. Biopsies of marrow revealed myeloid hypoplasia and nonspecific increases in iron deposition. The authors conclude that some workers are suffering from subclinical toxicity, with glycol ethers being responsible. Substitute materials should be used or exposure reduced.
Keywords
NIOSH-Author; NIOSH-Health-Hazard-Evaluation; NIOSH-Technical-Assistance-Report; Region-1; Chromatographic-analysis; Blood-analysis; Employee-exposure; Hazard-Confirmed; HETA-81-304-1361; Author Keywords: Commercial Printing, Lithographic; Dipropylene Glycol Monomethyl Ether; Ethylene Glycol Monomethyl Ether; Glycol Ether; Bone Marrow Injury; Aplastic Anemia
CAS No.
20324-32-7
Publication Date
19830801
Document Type
Field Studies; Hazard Evaluation and Technical Assistance
Fiscal Year
1983
NTIS Accession No.
PB85-159804
NTIS Price
A03
Identifying No.
HETA-81-304-1361
NIOSH Division
DSHEFS
SIC Code
2752
Source Name
National Institute for Occupational Safety and Health
State
CT; OH
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