Mechanism of action: carcinogenic o-methylarylamines.
Weisburger-JH; Fiala-ES; Hecht-SS
American Health Foundation, Hammond House Road, 1982 Jan; :1-39
The carcinogenicity of 3,2'-dimethyl-4-aminobiphenyl (13394860) (DMAB) and 3-methyl-2-naphthylamine (10546244) (MNA) was investigated in F344-rats, Charles-River-CDF-rats, Syrian-golden- hamsters, and guinea-pigs. Mutagenicity of aniline (62533) derivatives, MNA, DMAB, and ortho-toluidine (95534) was determined in Salmonella-typhimurium strains TA-100, TA-1535, and TA-1538, with or without rat liver S9 fraction. Rats and hamsters were given subcutaneous injections of MNA or DMAB for various periods then killed and necropsied. Rats were compared to hamsters in terms of susceptibility to DMAB carcinogenesis. Tritiated DMAB was given to hamsters and F344-rats. Bile was collected in cannulated animals and urine and feces were collected from nonoperated animals. DMAB produced mainly urinary bladder tumors in hamsters; MNA was less active, but caused local sarcoma at the injection site. Treatment with disulfiram (97778) decreased DMAB carcinogenicity in the small intestine in hamsters, while rats developed bladder tumors. No effect was seen on colon cancers. Prostate carcinomas occurred in male rats given DMAB but none were seen in hamsters. In Salmonella, compounds having a methyl group ortho to the amine were more mutagenic. Greater amounts of DMAB were excreted in the bile of rats than in hamsters. Hamsters excreted DMAB in urine, whereas rats did not.
NIOSH-Grant; Bladder-disorders; Carcinogens; Poisons; Industrial-chemicals; Cytotoxic-effects; Animal-studies; Safety-research
13394-86-0; 10546-24-4; 62-53-3; 95-53-4; 97-77-8
Final Grant Report
NTIS Accession No.
American Health Foundation, Hammond House Road
American Health Foundation Hammond House Road Valhalla, N Y 10595