Leukemia in benzene workers.
Infante-PF; Rinsky-RA; Wagoner-JK; Young-RJ
J Environ Pathol Toxicol 1979 May/Jun; 2(5):251-257
The development of leukemia in benzene (71432) workers was investigated. A retrospective cohort study of white male workers who were exposed to benzene from 1940 to 1949 was carried out. Follow up was attempted from date of first employment until 1975. Causes of death were determined from death certificates and were coded according to the International Classification of Diseases. The comparison groups consisted of white males standardized for age and time period over which the study cohort lived. The second group consisted of 1,447 white males who had been employed in Ohio at a fibrous glass construction products factory from 1940 to 1949 and had been employed for 5 or more years by 1972. There were 140 observed deaths from all causes among benzene exposed workers. The expected number was 187.6. There was an excess of deaths from malignancy of the lymphatic and hemopoietic systems. This was due to an excess of leukemia deaths. There had been seven leukemia deaths observed when the expected rate was 1.38. All seven leukemia deaths were of the myelogenous or monocytic type. Of the total expected number of incidence cases of leukemia, 50.37 percent were of the myelogenous and monocytic types. Pliofilm workers exposed to benzene had an estimated 10 fold risk of dying from myelogenous and monocytic leukemia. The authors conclude that the increased risk of leukemia in workers exposed to benzene will stimulate efforts to control occupational and consumer exposure to benzene.
NIOSH-Author; Industrial-environment; Chemical-analysis; Environmental-factors; Environmental-health-monitoring; Industrial-exposures; Chemical-industry-workers; Toxicology; Exposure-levels
Journal of Environmental Pathology and Toxicology. Toxicological and Carcinogenic Health Hazards in the Workplace: proceedings of the First Annual NIOSH Scientific Symposium, Cincinnati, Ohio, April 1978