Immunology of Grain and Other Organic Dusts.
NIOSH 1982:15 pages
The interactions between organic dusts and the human and animal complement systems are reviewed, and gram negative bacterial endotoxins are discussed. A comprehensive series of experiments with grain dust, Aspergillus, and cotton dust samples are reported. These experiments were designed to study the mechanisms involved in nonspecific activation of immunologic events which result in inflammation. It is noted that grain dust consists of a heterogenous mixture of materials which have not been adequately characterized. The role of Aspergillus-flavus in producing toxic, mutagenic, carcinogenic, and teratogenic responses is considered. The complement dependent respiratory impairment in an animal model of acute allergic lung disease using Aspergillus as an inhalant antigen is explored. Experiments monitoring the acute pulmonary responses to cardroom cotton dust in experimental animals are cited. Preliminary investigations of endotoxins in animal confinement units which showed that settled and airborne dusts from swine and poultry houses contain large amounts of gram negative bacterial endotoxins are noted. The author concludes that those involved in farming, grain handling, animal rearing, textile manufacturing, and sewage treatment are at risk to dust and contaminant exposures.
NIOSH-Author; Dust-exposure; Allergic-reactions; Airborne-particles; Lung-disorders; Pulmonary-function; Toxic-effects; Sampling-methods; Laboratory-testing;
NTIS Accession No.
NIOSH, U.S. Department of Health and Human Services, Morgantown, West Virginia, NTIS PB83-232-041, 15 pages, 23 references