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Carcinogenicity Of Azo Dyes: Acid Black 52 And Yellow 3 In Hamsters And Rats, Volume 1.

Plankenhorn LJ

NIOSH 1983 Sep:231 pages

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00130914

The effects of Acid-black-52 (5610640) (AB) and Yellow-3 (1342296) were studied in rats and hamsters. AB and Yellow-3 were administered intratracheally to Golden-Syrian-hamsters and Fischer- 344-rats once a week for 15 weeks at concentrations of 0.56 to 3.16 milligrams per 0.2 milliliters of saline solution. Both were also administered orally for 27 months, the former at 2 percent and the latter at 0.8 percent in the diet. Animals were observed for clinical symptoms during the experiments. At the end of the experiments, all animals were killed, and complete necropsies and histopathological studies were conducted. AB was not found to be oncogenic in either species by either route of administration. Yellow-3 given intratracheally was oncogenic in the adrenal cortex of male hamsters and in the pancreas of male rats. Yellow-3 administered in the diet was oncogenic in the adrenal glands of both sexes of hamsters, in the liver and urinary tract of male rats, and in the endocrine system of female rats. The author concludes that AB is noncarcinogenic and Yellow-3 is carcinogenic in rats and hamsters.

NIOSH-Contract; Dye-industry; Animal-studies; Medical-research; Toxicopathology; Pathomorphology; Body-retention; Safety-research; Contract-210-78-0032;

5610-64-0; 1342-29-6;

19830930

Contract;

1983

PB84-201136

A12

Contract-210-78-0032

Experimental Toxicology Branch, NIOSH