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Angiosarcoma of the liver in vinyl chloride/polyvinyl chloride workers.

Lloyd JW
J Occup Med 1975 May; 17(5):333-334
Cases of angiosarcoma of the liver in vinyl-chloride (75014) and polyvinyl-chloride (9002862) workers are reviewed. In January, 1974, three cases of angiosarcoma of the liver were reported among employees of a single vinyl-chloride polymerization facility. Subsequently 29 additional cases were recognized from the United States and nine other nations. All but three were diagnosed within the 7 years preceding 1975. An exact estimate of the incidence of angiosarcoma of the liver among polymerization workers cannot be determined but it is apparent that these workers are at high risk. About 5,600 workers are currently employed at 36 facilities in the United States. All the facilities from which angiosarcoma of the liver have been reported have been in operation more than 25 years. So far, 15 cases of liver angiosarcoma have been reported in the United States. Nine cases have been found in a facility employing fewer than 300 workers. The average latent period from first exposure to diagnosis is about 19 years. Consequently, most cases are appearing in the older facilities. It appears that these workers are also at high risk for other malignant neoplasms. Cases of angiosarcoma have been reported in other workers with exposure to vinyl-chloride. The relative youth of these workers in comparison with workers in the general population with liver cancer suggests a common etiology although the cause and effect relationship to vinyl- chloride exposure cannot be established. The author concludes that polymerization workers may not be the only industrial population at risk from exposure to vinyl-chloride or polyvinyl-chloride.
JOCMA7; NIOSH-Author; Industrial-environment; Occupational-exposure; Chemical-analysis; Analytical-models; Exposure-levels; Physiological-measurements; Quantitative-analysis; Hygiene; Workplace-studies
75-01-4; 9002-86-2
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Journal Article
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Journal of Occupational Medicine
Page last reviewed: November 6, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division