Determining the Role of Pulmonary Fibrosis in the Etiology of Lung Cancer, Report No. PB83-244-301.
Renne-RA; Eldridge-SR; Stevens-DL
NIOSH 1982 Mar:73 pages
The effects of four particulate materials on the production of pulmonary fibrosis was studied in hamsters. Four doses of quartz (14808607) ranging from 0.03 to 6.0 milligrams (mg), a 1 to 1 mixture of quartz and ferric-oxide (1309371) at 0.03 to 6.0mg each, (1333842) were given to Syrian-Golden-hamsters in 15 weekly intratracheal instillations. Saline control and caged control hamsters were also maintained. Mortality and histopathologic evidence of pulmonary fibrosis were recorded. Mortality in the saline control group was similar to that in the caged controls. Among the four dose groups for each test material, dose related mortality rates were evident only in animals receiving 6.0 or 3.3mg quartz per week, or 6.0 or 3.3mg each of quartz and ferric-oxide. Survival of these animals was significantly decreased. Survival of animals receiving 2.0 or 0.2mg hydrated alumina was significantly decreased, but not dose dependent. Alveolar septal fibrosis was produced in all experimental groups at rates and at greater severity than in control animals. In general, increased doses of quartz or quartz/ferric-oxide produced fibrosis of greater severity and higher incidence. Incidence and severity of septal fibrosis in groups exposed to fibrous glass or hydrated alumina were not clearly dose related. However, the groups exposed to the highest doses of either material (10.0mg fibrous glass and 20.0mg hydrated alumina) had the highest incidence of septal fibrosis. The pulmonary fibrotic response to fibrous glass or hydrated alumina was much less striking than the response to quartz/ferric-oxide or to quartz alone. The authors suggest that development of an animal model to study the role of pulmonary fibrosis in lung cancer should be based on the use of multiple instillations of quartz in rats. Quartz produces pronounced pulmonary fibrosis and is less likely to increase mortality significantly in rats than in hamsters.
NIOSH-Contract; Disease-incidence; Biological-effects; Dose-response; Pulmonary-disorders; Toxic-effects; Biological-factors; Mortality-data; Animal-studies; Contract-210-79-0038;
14808-60-7; 1309-37-1; 1333-84-2;
NTIS Accession No.
Division of Biomedical and Behavioral Science, NIOSH, U.S. Department of Health, Education, and Welfare, Cincinnati, Ohio