The influence of the thyroid on the acute toxicity of a dynamite- sensitizing mixture (36135).
Proc Soc Exp Biol Med 1972 Jan; 139(1):323-324
The influence of thyroid hormone on the acute toxic response to a dynamite sensitizing mixture was investigated. Male CFN-rats were divided into three groups for the hyperthyroid study: one group received thyroxine (7488702); one received triiodothyronine (6893023); and one received sodium-hydroxide (1310732). For the hypothyroid studies, rats were thyroidectomized and maintained on 1 percent calcium-lactate in drinking water. After 18 or 28 days, animals were challenged with an the median lethal dose of a mix of organic nitrates. Pretreating rats with thyroid hormone resulted in increased sensitivity to the mix. Conducting a thyroidectomy, followed by a depletion period made the rats resistant to the organic nitrate mixture. The author concludes that since hyperthyroidism potentiates the toxicity of dynamite mix while hypothyroidism protects against it demonstrates that the thyroid system has a profound influence on the acute toxicity of organic nitrates.
NIOSH-Author; Animal-studies; Hormones; Thyroid-gland; Thyroid-gland-disorders; Sensitization; Metabolic-study; Organic-compounds; Biological-effects
7488-70-2; 6893-02-3; 1310-73-2
Proceedings of the Society for Experimental Biology and Medicine