Pathology of carcinoma of the lung associated with asbestos exposure.
Cancer 1972 Jul; 30(1):14-21
The pathology of lung cancer associated with asbestos (1332214) exposure was investigated. Fifty cases of carcinoma of the lung in subjects occupationally exposed to asbestos were compared with 50 comparison cases with no history of asbestos exposure or presence of asbestos bodies in lung sections. Tumors were classified according to cell type, location, and the presence of asbestos fibers while other features of the lungs were also noted. Asbestos related tumors occurred more frequently in the lower lobe; tumors in comparisons were more often found in the upper lobe. Of the 50 asbestos related cancers, 11 were adenocarcinomas, 6 were anaplastic large cell tumors, 8 showed a combination of cell types, and 3 were unclassified. Comparison tumors were: 12 squamous; 14 anaplastic small cell; 9 adenocarcinoma; 8 anaplastic large cell; and 7 combined. Five asbestos associated cancers showed extensive pleural spread compared with one comparison cancer. A moderate number of comparisons had mild fibrosis, and a few had more advanced fibrosis; however, much more frequent and higher grades of fibrosis were seen in the asbestos associated cases. No apparent correlation between the number of asbestos bodies and fibrosis could be determined in the areas examined. The author concludes that predominance of lower lobe tumors in the asbestos exposed group is the outstanding difference between the two groups. A somewhat greater tendency to pleural involvement in the asbestos associated series is also significant. These two differences may result from structural alterations in the lungs preceding neoplasia; however, the character of tissue reaction is essentially the same in both asbestos associated and other lung cancers.
NIOSH-Publication; NIOSH-Grant; Case-studies; Occupational-exposure; Pathogenesis; Toxicology; Carcinogenicity; Lung-irritants; Toxic-effects; Tumorigenesis; Disease-incidence
Community Medicine MT Sinai School of Medicine Fifth Avenue and 100 Street New York, N Y 10029
Mount Sinai School of Medicine, New York, New York