Health hazard evaluation report: HETA-80-79-1189, Rexall Drug Company, St. Louis, Missouri.
Watanabe AS; Ruhe RL; Hervin RL
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, HETA 80-79-1189, 1982 Sep; :1-25
Chemical exposures at the Rexall drug manufacturing facility (SIC- 2834), St. Louis, Missouri were investigated. The study was requested by the Oil, Chemical, and Atomic Workers International Union because of employee reports of nosebleeds, discolored urine, chest tightness, and breathing difficulties. The survey was performed in February, April, and July 1981. Environmental and medical evaluations were conducted. Total particulate concentrations in personal breathing zones ranged from 0.4 to 32.5 milligrams per cubic meter (mg/m3) compared to an American Conference of Governmental Industrial Hygienists threshold limit value (TLV) of 5.0mg/m3. Ferrous-sulfate (10028225) concentration peaked at 7.83mg/m3 (TLV: 1mg/m3). Methylene-chloride (75092) concentrations peaked at 361mg/m3 (NIOSH criteria: 261mg/m3). Isopropyl-alcohol (67630) concentrations peaked at 1180mg/m3 (NIOSH criteria: 984mg/m3). Five of seven ferrous-sulfate workers reported cough, nose, throat, or skin irritation, or headache. All four employees who worked with ferrous-sulfate on 2 consecutive days had increases both in serum iron concentrations and percent saturation of iron binding capacity. Eleven of 13 niacin workers reported skin symptoms. The authors conclude that a health hazard did exist due to high exposure to total dust, ferrous-sulfate, isopropyl-alcohol, and methylene-chloride. The authors recommend a respirator program and engineering controls.
NIOSH-Author; NIOSH-Health-Hazard-Evaluation; Hazards-Confirmed; Pharmaceutical-industry; Environmental-health-monitoring; Medical-monitoring; Respiratory-protective-equipment; Dust-exposure; Region-7; HETA-80-79-1189; NIOSH-Technical-Assistance-Report;
Author Keywords: Pharmaceutical Preparations; total and respirable dusts; ferrous sulfate; niacin; Nicotinic Acid; zinc gluconate; methylene chloride; methyl alcohol; isopropyl alcohol
10028-22-5; 75-09-2; 67-63-0
Field Studies; Hazard Evaluation and Technical Assistance
NTIS Accession No.
National Institute for Occupational Safety and Health