An Electrodiagnostic Study of the Neurotoxicity of Methyl n-Amyl Ketone (Preliminary Report).
Johnson BL; Setzer JV; Lewis TR
NIOSH 1976 Feb:20 pages
The neurotoxic properties of methyl-n-amyl-ketone (110430) (MAK) were investigated using electrophysiological methods. Male albino- Sprague-Dawley-rats and male Macaca-fascicularis-monkeys were exposed to 100 and 1000 parts per million MAK for 6 hours per day 5 days per week for up to 5 months. There were 10 rats and 8 monkeys for each exposure condition. Animals were neurologically tested at monthly intervals for maximum motor conduction velocity (MCV) of the sciatic peroneal and ulnar nerves, the amplitude of muscle action potentials (MAP), electroencephalogram, and visual evoked potentials. Body weights were measured. The values of MCV were not significantly different from controls in exposed monkeys or rats, nor were MAPs related to MAK exposure. No effects of MAK were found in amplitude or latencies of component peaks or averaged visual evoked potentials from monkeys, nor were there observable electroencephalogram abnormalities. Both species continued to gain weight throughout the 5 months of MAK exposure, and the rates of body weight gain were found to be unrelated to exposure. No observable changes in movement were noted after MAK exposure. The authors conclude that after 5 months of MAK exposure, no statistically significant neurotoxic effects are noted in either monkeys or rats.
Animal-studies; Chemical-properties; Exposure-limits; Neurological-reactions; Electrophysiological-effects; Neurotoxicology; Physiological-response; Ketones; Electrophysiological-examinations;
Division of Biomedical and Behavioral Science, NIOSH, Center for Disease Control, U.S. Public Health Service, U.S. Department of Health, Education and Welfare, Cincinnati, Ohio, 20 pages, 16 references