NIOSHTIC-2 Publications Search
Investigation of an apparent increased prevalence of brain tumors in a U.S. petrochemical plant.
Alexander V; Leffingwell SS; Lloyd JW; Waxweiler RJ; Miller RL
Ann NY Acad Sci 1982 Apr; 381(1):97-107
An apparent increased prevalence of brain tumor deaths in a petrochemical facility in Texas was investigated. These studies were a part of more complete occupational health evaluation undertaken by OSHA, NIOSH and the company. Twenty cases of primary brain cancer death were examined using work history data. The interval from first employment to death varied from 3.5 to 36 years, with a median of 24 years. All cases occurred in males; 80 percent of the tumors were glioblastomas. Preliminary examination of work histories failed to establish any common job title, department code or chemical exposure. Mortality studies revealed an excess brain cancer risk among rubber (SIC-3069), pharmaceutical (SIC-2834), vinyl-chloride (75014) (SIC-2821), chemists (SIC-8071), and petrochemical and oil refinery workers (SIC-2911). An elevated risk was observed among veterinarians (SIC-0742), machinists (SIC-3599), lead smelter (SIC-3332) and aluminum reduction (SIC-3334) workers. No specific causative agents were clearly identified, with the exception of vinyl-chloride. The authors conclude that these tumors are the likely result of occupational chemical exposures.
NIOSH-Author; Health-surveys; Epidemiology; Industrial-hygiene; Industrial-chemicals; Medical-research; Cancer-rates; Mortality-rates
Issue of Publication
3069; 2834; 2821; 8071; 2911; 3599; 3332; 3334
Annals of the New York Academy of Sciences
TX; DC; OH
Page last reviewed: November 6, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division