Prenatal interactions between ethanol and the industrial solvent 2- ethoxyethanol in rats: maternal and behavioral teratogenic effects.
Nelson-BK; Brightwell-WS; Setzer-JV
Neurobehav Toxicol Teratol 1982 Jan; 4(3):387-394
The interaction between ethanol (64175) and ethoxyethanol (110805) in producing prenatal maternal behavioral and teratogenic effects in rats was studied. A total of 119 pregnant female Sprague-Dawley- rats were exposed to 10 percent ethanol as the sole liquid source; some were also exposed to 100 parts per million (ppm) 2- ethoxyethanol at 7 to 13 or 14 to 20 days of gestation; and some were exposed instead to 200ppm 2-ethoxyethanol at 7 to 13 days of gestation. Maternal weight gain and intake were tabulated. Behavior of the offspring was tested to evaluate central nervous system function at several stages of development. Administration of 200ppm 2-ethoxyethanol on gestation days 7 to 13 produced a consistent deviation pattern: maternal weight gain was reduced, gestation was prolonged, and performance in rotorod testing, open field activity, and avoidance conditioning was decreased. The combination of 10 percent ethanol and 100ppm 2-ethoxyethanol on gestation days 14 to 20 produced some of these deviations: gestation was prolonged and offspring were less active in open field and avoidance testing. The authors conclude that ethanol late in gestation may enhance the effects of prenatal 2-ethoxyethanol.
NIOSH-Author; Toxicology; Neurotoxins; Organic-solvents; Teratogenicity; Teratology; Teratogenesis; Synergism
Mixed Exposures; Work Environment and Workforce
Neurobehavioral Toxicology and Teratology