Tier II Mutagenic Screening of 13 NIOSH Priority Compounds, Individual Compound Report, 3-Chloropropene.
NIOSH 1981 Jul:191 pages
Allyl-chloride (107051) (AC) was subjected to a tier II mutagenic test screening program. The assays included unscheduled DNA synthesis (UDS) assay in human diploid fibroblasts with exposures of 3 hours duration and concentrations of up to 9900 micrograms per milliliter of culture medium; dominant lethal test in male rats with exposure to atmospheres containing 1 part per million (ppm) or 25ppm AC for 7 hours per day for 5 days; sperm abnormality test in male mice using the same conditions; cytogenetic tests in male and female rat bone marrow cells using the same exposure conditions or a single exposure of 7 hours duration; and sex linked recessive lethal test in Drosophila-melanogaster with exposure to atmospheres of 150ppm for 7 hours. There was no increase in UDS in cells treated with AC nor were there increases in the frequencies of cells with aberrations seen as a result of examination of bone marrow metaphase cell analysis. There were not effects of AC in the dominant lethal test on pregnancy, numbers of corpora lutea graviditatis or implantations, or the frequency of early deaths. Sperm abnormality frequency was not affected by treatment and sex linked recessive lethal mutation frequency was not increased. The author concludes that AC was devoid of genetic effects.
NIOSH-Contract; Contract-210-78-0026; Mutagenesis; Toxicology; Bioassays; Screening-methods; Genetic-disorders;
NTIS Accession No.
Inveresk Research International Limited, Musselburgh, Scotland, NIOSH, Cincinnati, Ohio, No. 39, 191 pages, 20 references