NIOSHTIC-2 Publications Search

Tier II mutagenic screening of 13 NIOSH priority compounds, individual compound report, bis(2-methoxyethyl) ether.

Authors
McGregor DB
Source
Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Contract 210-78-0026, 1981 Jul; :1-185
NIOSHTIC No.
00123528
Abstract
Bis(2-methoxyethyl)-ether (111966) (BME) was subjected to a tier II mutagenic screening program. Screening assays included unscheduled DNA synthesis (UDS) assay in human diploid fibroblasts with exposures of 3 hours duration and concentrations up to 19,000 micrograms per milliliter of culture medium; dominant lethal test in male rats with exposures to atmospheres containing 250 parts per million (ppm) or 1000ppm BME for 7 hours per day for 5 days; sperm abnormality test in male mice using the same exposures conditions; cytogenetic test in male and female rat bone marrow cells using the same exposure conditions or a single exposure of 7 hours duration; sex-linked recessive lethal test in Drosophila-melanogaster with exposure to atmospheres of 250ppm for 2.75 hours. There was no increase in UDS in cells treated with BME; clinical signs of toxicity occurred in animals exposed to 1000ppm BME atmospheres; male rat fertility was drastically reduced following exposure to 1000ppm BME in the dominant lethal test; a significant reduction in total aberrant cell frequency occurred; and abnormal sperm frequency was increased. The author concludes that BME may be a weak mutagen, but the adverse effect upon reproductive capacity is probably the more important aspect of its toxicology.
Keywords
NIOSH-Contract; Contract-210-78-0026; Screening-methods; Bioassays; Mutagenesis; Toxicology; Genetic-disorders
CAS No.
111-96-6
Publication Date
19810707
Document Type
Final Contract Report
Funding Type
Contract
Fiscal Year
1981
NTIS Accession No.
PB83-138198
NTIS Price
A10
Identifying No.
Contract-210-78-0026
Source Name
National Institute for Occupational Safety and Health
State
OH
Performing Organization
Inveresk Research International Limited, Musselburgh, Scotland
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division