NIOSHTIC-2 Publications Search

Tier II mutagenic screening of 13 NIOSH priority compounds, individual compound report, styrene oxide.

Authors
McGregor DB
Source
Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Contract 210-78-0026, 1981 Feb; :1-172
Link
NIOSHTIC No.
00123525
Abstract
Styrene-oxide (96093) (SO) was subjected to a tier II mutagenic test screening program. The screening included the following assays: unscheduled DNA synthesis (UDS) assay in human diploid fibroblasts with exposures of 3 hours duration and concentrations up to 50 micrograms per milliliter of culture medium; dominant lethal test in male rats with exposure to atmospheres containing 15 or 100 parts per million (ppm) SO styrene-oxide for 7 hours per day for 5 consecutive days; sperm abnormality test in male mice using the same conditions; cytogenetic test in male and female rat bone marrow cells using the same exposure conditions or a single exposure of 7 hours duration; and sex linked recessive lethal test in Drosophila- melanogaster with exposure of 100ppm for 150 minutes. There was no increase in UDS in cells treated with SO and the frequencies of chromosomal aberrations were not increased in the rat bone marrow cells. There was a small effect attributable to SO in the dominant lethal test on pregnancy frequency and on the total number of implantations. Sperm abnormality frequency was slightly increased in mice dosed with 100 parts per million SO, while sex linked recessive lethal mutation frequency was not increased. The author concludes that SO did not show genetic effects detectable in the experiments apart from the small increase in the frequency of sperm with abnormalities.
Keywords
NIOSH-Contract; Contract-210-78-0026; Genetic-disorders; Mutagenesis; Toxicology; Polymers; Bioassays; Screening-methods
CAS No.
96-09-3
Publication Date
19810220
Document Type
Final Contract Report
Funding Type
Contract
Fiscal Year
1981
NTIS Accession No.
PB83-130203
NTIS Price
A09
Identifying No.
Contract-210-78-0026
Source Name
National Institute for Occupational Safety and Health
State
OH
Performing Organization
Inveresk Research International Limited, Musselburgh, Scotland
Page last reviewed: October 11, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division