Mortality Study of Workers Employed at Organochlorine Pesticide Manufacturing Plants.
Brown-DP; Ditraglia-D; Namekata-T; Iverson-N
NIOSH 1980 May:206-228
Mortality of workers employed in the manufacture of chlorinated hydrocarbon pesticides was studied. A retrospective cohort study involving a total of 2100 persons who had been employed for at least 6 months prior to January, 1964, was conducted in four manufacturing facilities producing chlordane (57749), heptachlor (76448), dichlorodiphenyltrichloroethane (50293) (DDT), or aldrin (309002), dieldrin (60571), and endrin (72208). Vital status of 90 to 97 percent of study cohort members as of December 31, 1976, was determined. Cause of death for all known dead was determined from death certificates. Expected cause specific mortality rates were calculated using a modified life table analysis program and comparison with observed deaths. The standardized mortality ratio (SMR) for all causes of death in each cohort was below expected, ranging from 66 to 82. SMRs ranged from 68 to 91 for all malignant neoplasms and from 55 to 132 for respiratory cancer. The chlordane factory had a slight excess of stomach cancer deaths. The aldrin, dieldrin, and endrin facility had an excess of esophagus, rectum, liver, and lymphatic and hematopoietic system cancers and a higher than expected incidence of pneumonia and other respiratory diseases. The authors conclude that the number of workers involved and number of deaths that occurred are too small to make any valid associations between cause specific mortality and employment at the pesticide factories.
Chemical-manufacturing-industry; Chemical-industry-workers; Pesticides-and-agricultural-chemicals; Epidemiology; Mortality-rates; Carcinogenesis; Humans;
57-74-9; 76-44-8; 50-29-3; 309-00-2; 60-57-1; 72-20-8;
Proceedings of the First NCI/EPA/NIOSH Collaborative Workshop: Progress on Joint Environmental and Occupational Cancer Studies, May 6-8, 1980, Rockville, Maryland, H. F. Kraybill, I. C. Blackwood, and N. B. Freas, Eds. National Cancer Institute, Environmental Protection Agency, National Institute for Occupational Safety and Health