Studies of Organ-Associated Antigens and Other Markers in Human Tumors Which May be Useful for the Diagnosis of Malignant Diseases.
NIOSH 1980 May:327-332
Ongoing studies to develop immunologic or other diagnostic markers as cancer screening tests are described. A test for leukemias and lymphomas involved preparation of heterologous antisera, primarily in rabbits, that reacted against antigens associated with different types of human leukemias. Attempts to improve specificity and develop large amounts of reagents have involved the production of monoclonal antibodies in mice to detect various series of antigens. A second research project involved a marker called EDCI, a low molecular weight protein found in the urine of cancer patients, which was considered potentially useful in screening for breast cancer. Problems in improving the sensitivity and specificity of the EDCI test are discussed. The author concludes that the tests described have potential use in screening for leukemia and breast cancer, with possibilities for other types of cancer as well.
Medical-screening; Biochemical-tests; Immunology; Diagnostic-tests; Diagnostic-techniques; Carcinogenesis; Medical-monitoring;
Proceedings of the First NCI/EPA/NIOSH Collaborative Workshop: Progress on Joint Environmental and Occupational Cancer Studies, May 6-8, 1980, Rockville, Maryland, H. F. Kraybill, I. C. Blackwood, and N. B. Freas, Eds. National Cancer Institute, Environmental Protection Agency, National Institute for Occupational Safety and Health