Development of a strain of mice for studies of photocarcinogenesis is described. Different hairless mouse strains were exposed five times a week for specified lengths of time to ultraviolet-B irradiation in a solar simulator. Responses were recorded at 24 weeks in terms of tumor incidence and size. The strains varied greatly both in the number of mice affected and the number of tumors on affected mice. Cryptothrix and absebia strains were the most resistant to tumor formation, while the Skh-1 and HRA stains were the most susceptible. Susceptibility was not correlated with either the albino gene or the hairless gene. The strain chosen for further study was an inbred strain designated HRA/Skh. The importance of acceptance of a hairless mother in large scale production of a line is discussed.
Proceedings of the First NCI/EPA/NIOSH Collaborative Workshop: Progress on Joint Environmental and Occupational Cancer Studies, May 6-8, 1980, Rockville, Maryland, H. F. Kraybill, I. C. Blackwood, and N. B. Freas, Eds. National Cancer Institute, Environmental Protection Agency, National Institute for Occupational Safety and Health