Chronic cadmium exposure: relation to male reproductive toxicity and subsequent fetal outcome.
Zenick-H; Hastings-L; Goldsmith-M; Niewenhuis-RJ
J Toxicol Environ Health 1982 Jan; 9(3):377-387
The reproductive effects of chronic cadmium (7440439) (Cd) exposure were studied in male rats. Twenty, 100 day old proven fertile male Sprague-Dawley-rats were assigned to one of four treatment groups and for 70 to 80 days given 0, 17, 34, or 69 parts per million (ppm) Cd as in distilled water. Weekly weight, fluid and food consumption were recorded. At approximately 170 days of age, each male was mated to three female rats, one of which on day 20 of pregnancy was killed for prenatal evaluation. After the third mating each male was killed. Testes and caudal epididymides were removed for histological and spermatogonia evaluation and Cd concentrations in the kidney and liver were determined. Differences in the lower body weights at the higher level of Cd exposure were insignificant. Cd concentrations increased greatly in the kidney, but remained below 200ppm, wet weight needed for detectable renal dysfunction. Male fertility was not affected by the Cd treatment. The authors conclude that Cd orally administered in water concentrations up to 69ppm does not significantly affect reproductive functions. They recommend further reevaluation of the classic view of Cd related testicular injury.
NIOSH-Publication; NIOSH-Grant; Reproductive-system-disorders; Heavy-metals; Laboratory-animals; Body-distribution; Cadmium-poisoning; Toxicology; Sex-factors
Environmental Health University of Cincinnati 3223 Eden Avenue Cincinnati, Ohio 45267
Journal of Toxicology and Environmental Health
University of Cincinnati, Cincinnati, Ohio