Lead, hypertension, and the renin-angiotensin system in rats.
Victery-W; Vander-AJ; Shulak-JM; Schoeps-P; SJulius-S
J Lab Clin Med 1982 Mar; 99(3):354-362
The effect of lead (7439921) exposure on the production of hypertension and on the renin angiotensin system (RAS) was investigated in rats. Pregnant Charles-River-rats were fed water containing 0, 100 or 500 parts per million (ppm) lead during pregnancy and lactation. The regimen was continued after weaning. Blood pressure recordings were obtained monthly in all male offspring by the tail cuff method. Animals were sacrificed at 6 months of age to evaluate the RAS in a basal state. Some animals were subjected to pentobarbital anesthesia, laparotomy and aortic puncture to permit evaluation of the effect of lead on plasma renin activity (PRA) during stimulated renin release. Rats that received 100ppm of lead developed a significant elevation of systolic blood pressure; rats that received 500ppm remained normotensive. The PRA was significantly reduced after 6 months in males receiving 100ppm lead; PRA was normal in the 500ppm group. The authors conclude that blood lead values commonly encountered in individuals are capable of inducing moderate hypertension in male rats while higher doses failed to do so. They suggest that since the hypertension is associated with a reduction in PRA, it is unlikely to be due to hyperactivity of the RAS.
NIOSH-Publication; NIOSH-Grant; Cardiovascular-system-disorders; Heavy-metals; Hypertension; Laboratory-animals; Toxicology; Hematology; Lead-poisoning; Blood-plasma
Physiology University of Michigan 6811 Medical Science II Ann Arbor, Mich
Other Occupational Concerns; Grants-other
The Journal of Laboratory and Clinical Medicine
University of Michigan at Ann Arbor, Ann Arbor, Michigan