NIOSHTIC-2 Publications Search

Neuropathological evaluation of monkeys exposed to ethylene and propylene oxide.

Authors
Sprinz-H; Matzke-H; Carter-J
Source
NIOSH 1982 Feb; :1-9
Link
NIOSHTIC No.
00122451
Abstract
The neuropathological effect of ethylene-oxide (75218) and propylene- oxide (75569) on monkeys was studied. Male monkeys were exposed to and 300ppm propylene-oxide at 6 hours per day, 5 days per week for 2 years. Brain, ulnar and sciatic nerves, and spinal cord tissue were examined histologically. No differences were found between controls and chemically treated animals, between sciatic and ulnar nerves, and between different levels of these nerves. The eight segments of spinal cord of control and experimental animals had no specific pathological differences. In the medulla oblongata of the brain, ethylene-oxide and propylene-oxide exposed monkeys had signs of axonal distrophy. Ethylene-oxide exposed monkeys also had signs of demyelination in this area of the brain. The author concludes that the concern expressed by OSHA about the allowable maximal amount of ethylene-oxide is strengthened by the result of the present study. Also, in view of the current great interest in the effect of chronic occupational exposure to the two compounds, additional studies would seem justified.
Keywords
NIOSH-Contract; Contract-210-81-6004; Oxides; Central-nervous-system; Nervous-system-disorders; Comparative-toxicology; Neurotoxicity
CAS No.
75-21-8; 75-56-9
Publication Date
19820208
Document Type
Final Contract Report
Funding Type
Contract
Fiscal Year
1982
NTIS Accession No.
PB83-134817
NTIS Price
A02
Identifying No.
Contract-210-81-6004
Source Name
Midwest Research Institute, Kansas City, Missouri, NIOSH, Cincinnati, Ohio, 9 pages, 10 references
State
MO; OH
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division