Diverse profiles of immunoreactivity in toluene diisocyanate (TDI) asthma.
Gallagher JS; Tse CST; Brooks SM; Bernstein IL
J Occup Med 1981 Sep; 23(9):610-616
Immunoreactivity to mono and diisocyanate protein conjugates was evaluated in fifteen workers with toluene-diisocyanate (584849) (TDI) asthma and seventeen nonexposed volunteers. Intracutaneous skin tests, measurement of specific immunoglobulin to E by leucocyte inhibitory factor (LIF) tests were conducted using conjugates of human serum albumin and TDI (HSA-TDI) or hexamethylene-diisocyanate (822060) (HSA-HDI). Peripheral leucocytes of nine symptomatic workers produced LIF after exposure to HSA-TDI and four of these workers also exhibited LIF activity to HSA-HDI. No LIF activity was detected in nonexposed subjects or in a previously symptomatic worker removed from TDI exposure 7 years prior to testing.
JOCMA7; NIOSH-Publication; NIOSH-Grant; Organic-solvents; Immunology; Occupational-medicine; Hematology; Immune-reaction; Immunological-tests; Blood-cells
Internal Medicine University of Cincinnati 231 Bethesda Avenue Cincinnati, Ohio 45267
Journal of Occupational Medicine
University of Cincinnati, Cincinnati, Ohio