NIOSHTIC-2 Publications Search

Tier II mutagenic screening of 13 NIOSH priority compounds, individual compound report, 2-methoxyethanol.

Authors
McGregor D
Source
Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Contract 210-78-0026, 1980 Nov; :1-227
NIOSHTIC No.
00122313
Abstract
The Tier II mutagenic screening of 2-methoxyethanol (109864) is discussed. The properties, human exposure and toxicology of the compound are reviewed. The chemicals, animals, animal management and atmosphere generation, are described. The methods for DNA synthesis assay, cytogenetic analysis of rat bone marrow cells, dominant lethal testing, sperm abnormality analysis, sex linked recessive lethal test and statistical evaluation are discussed. Results of these analyses are presented. The author concludes that 2-methoxyethanol has a profound effect upon male fertility but does not induce chromosomal aberrations in rat bone marrow. Also, it is recommended that more detailed studies of the effects upon testicular cells be conducted to reach an understanding of the dominant lethal test and sperm abnormality test results.
Keywords
NIOSH-Contract; Contract-210-78-0026; Bioassays; Screening-methods; Medical-screening; Mutagenesis; Comparative-toxicology; Medical-research
CAS No.
109-86-4
Publication Date
19801101
Document Type
Final Contract Report
Funding Type
Contract
Fiscal Year
1981
NTIS Accession No.
PB83-113407
NTIS Price
A12
Identifying No.
Contract-210-78-0026
Source Name
National Institute for Occupational Safety and Health
State
OH
Performing Organization
Inveresk Research International Limited, Musselburgh, Scotland
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division