Tier II Mutagenic Screening of 13 NIOSH Priority Compounds, Individual Compound Report 2-Methoxyethanol.
NIOSH 1980 Nov:227 pages
The Tier II mutagenic screening of 2-methoxyethanol (109864) is discussed. The properties, human exposure and toxicology of the compound are reviewed. The chemicals, animals, animal management and atmosphere generation, are described. The methods for DNA synthesis assay, cytogenetic analysis of rat bone marrow cells, dominant lethal testing, sperm abnormality analysis, sex linked recessive lethal test and statistical evaluation are discussed. Results of these analyses are presented. The author concludes that 2-methoxyethanol has a profound effect upon male fertility but does not induce chromosomal aberrations in rat bone marrow. Also, it is recommended that more detailed studies of the effects upon testicular cells be conducted to reach an understanding of the dominant lethal test and sperm abnormality test results.
NIOSH-Contract; Contract-210-78-0026; Bioassays; Screening-methods; Medical-screening; Mutagenesis; Comparative-toxicology; Medical-research;
NTIS Accession No.
Inveresk Research International Limited, Musselburgh EH21 7UB, Scotland, NIOSH, Cincinnati, Ohio, No. 22, 227 pages, 21 references