NIOSHTIC-2 Publications Search
Tier II mutagenic screening of 13 NIOSH priority compounds, individual compound report, N-methyl dicyclohexylamine.
Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Contract 210-78-0026, 1981 Jun; :1-203
The Tier II mutagenic screening of N-methyl-dicyclohexylamine (7560830) is studied. The structure and toxicology of the compound is presented. The chemicals, animals, animal management and atmosphere generation involved with the studies are described. The methods for DNA synthesis assay, cytogenic analysis of rat bone marrow cells, dominant lethal testing, sperm abnormality tests in Drosophila melanogaster and statistical evaluation are discussed. The results of these analyses are presented. The author concludes that N-methyl-dicyclohexylamine has genotoxic properties and can not induce unscheduled DNA synthesis in cultured mammalian cells.
NIOSH-Contract; Contract-210-78-0026; Bioassays; Screening-methods; Medical-screening; Mutagenesis; Analytical-methods
Final Contract Report
NTIS Accession No.
National Institute for Occupational Safety and Health
Inveresk Research International Limited, Musselburgh, Scotland
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division