Tier II Mutagenic Screening of 13 NIOSH Priority Compounds, Individual Compound Report N-Methyl Dicyclohexylamine.
NIOSH 1981 Jun:203 pages
The Tier II mutagenic screening of N-methyl-dicyclohexylamine (7560830) is studied. The structure and toxicology of the compound is presented. The chemicals, animals, animal management and atmosphere generation involved with the studies are described. The methods for DNA synthesis assay, cytogenic analysis of rat bone marrow cells, dominant lethal testing, sperm abnormality tests in Drosophila melanogaster and statistical evaluation are discussed. The results of these analyses are presented. The author concludes that N-methyl-dicyclohexylamine has genotoxic properties and can not induce unscheduled DNA synthesis in cultured mammalian cells.
NIOSH-Contract; Contract-210-78-0026; Bioassays; Screening-methods; Medical-screening; Mutagenesis; Analytical-methods;
NTIS Accession No.
Inveresk Research International Limited, Musselburgh EH21 7UB, Scotland, NIOSH, Cincinnati, Ohio, No. 36, 203 pages, 10 references