NIOSHTIC-2 Publications Search

Tier II mutagenic screening of 13 NIOSH priority compounds, individual compound report, N-methyl dicyclohexylamine.

Authors
McGregor D
Source
Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Contract 210-78-0026, 1981 Jun; :1-203
NIOSHTIC No.
00122312
Abstract
The Tier II mutagenic screening of N-methyl-dicyclohexylamine (7560830) is studied. The structure and toxicology of the compound is presented. The chemicals, animals, animal management and atmosphere generation involved with the studies are described. The methods for DNA synthesis assay, cytogenic analysis of rat bone marrow cells, dominant lethal testing, sperm abnormality tests in Drosophila melanogaster and statistical evaluation are discussed. The results of these analyses are presented. The author concludes that N-methyl-dicyclohexylamine has genotoxic properties and can not induce unscheduled DNA synthesis in cultured mammalian cells.
Keywords
NIOSH-Contract; Contract-210-78-0026; Bioassays; Screening-methods; Medical-screening; Mutagenesis; Analytical-methods
CAS No.
7560-83-0
Publication Date
19810622
Document Type
Final Contract Report
Funding Type
Contract
Fiscal Year
1981
NTIS Accession No.
PB83-126607
NTIS Price
A11
Identifying No.
Contract-210-78-0026
Source Name
National Institute for Occupational Safety and Health
State
OH
Performing Organization
Inveresk Research International Limited, Musselburgh, Scotland
Page last reviewed: October 11, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division