A method for the sampling and analysis of respirable talc (14807966) in the air of the workplace environment was tested for NIOSH validation. Samples were collected on a 37 millimeter (mm) 0.45 micron Millipore polyvinyl-chloride filter, ashed at low temperature, transferred to a silver membrane filter, and analyzed by X-ray diffraction. The protocol for establishing NIOSH validation of the method was to analyze spiked samples collected from dynamically generated test atmospheres, test the efficiency of a 10mm nylon cyclone and the breakthrough capacity of a cellulose ester filter, test the storage stability of spiked and generated filters and assess the precision and accuracy of the method. The aerosol generation and sampling system was presented. The authors conclude that the method does not satisfy the criteria for NIOSH validation.