Neoplastic and nonneoplastic effects of vinyl chloride in mouse lung.
Environ Health Perspect 1981 Oct; 41:31-52
Neoplastic and nonneoplastic changes in the lung caused by vinyl- chloride (75014) were studied in mice. Twenty seven CDI-Charles- River-mice were exposed to vinyl-chloride 5 hours a day, 5 days a week at 2500 or 6000 parts per million (ppm) for 5 or 6 months. After recovery times of 2, 6, or 37 days, mice were sacrificed and lungs were examined by light and electron microscopy. Other groups of mice were given 100, 10, 1, or 0ppm of vinyl-chloride for 4 weeks and examined for neoplastic changes 40 weeks after exposure. Multiple pulmonary tumors arranged in tubulopapillary or adenomatous formations and corresponding to alveologenic tumors occurred in all but one of the 27 animals subjected to relative large vinyl-chloride doses over a long period. No metastases occurred, although there were occasional mitotic divisions and invaginations into the bronchiolar lumen. Major nonneoplastic effects of heavy doses and long term exposure were proliferation and hypertrophy of the bronchiolar epithelium, hypersecretion of the epithelial mucin in the goblet cells of the bronchi and proximal bronchioles, and chronic peribronchial or bronchiolar inflammation. The smaller dose and shorter term exposure to vinyl-chloride caused alveologenic tumors in 5 out of 9 mice exposed to 100ppm, 2 out of 9 exposed to 10ppm, 1 out of 9 exposed to 1ppm, and no tumors in 10 mice with no exposure. A dose relationship was suggested. The author concludes that the mouse lung is an extremely sensitive indicator of the oncogenicity of vinyl-chloride.
NIOSH-Publication; NIOSH-Grant; Vinyl-plastics; Chlorinated-ethylenes; Laboratory-animals; Lung-disorders; Lung-cancer; Carcinogenesis; Neoplasms; Histology
Community Medicine Mount Sinai School of Med Fifth Avenue & 100Th Street New York, N Y 10029
Environmental Health Perspectives
Mount Sinai School of Medicine, New York, New York