The health effects of occupational exposure to secondary and tertiary aliphatic monoamines are reviewed. The extent and degree of exposure through the natural occurrence of aliphatic amines in the environment and by occupational exposure are discussed. Patterns of worker exposure by occupational are described. The biological effect of exposure on humans are discussed, and the results of six epidemiologic studies are presented. A brief description of the toxic effects observed in animal experiments is provided, and limitations in this type of research are discussed. Metabolism studies of these amines are described, and the minimal extent of biochemical studies is noted. The mutagenic and carcinogenic potential and the reproductive effects of secondary and tertiary monoamines are described. Attempts to correlate amine toxicity to chemical structure are discussed, and the correlation of exposure and effect in humans and animals is described. Methods for sampling and analyzing secondary and tertiary aliphatic monoamines in workplace environments are described, and biological monitoring techniques are identified. Employee training, safety procedures, and protective measures are discussed, and engineering control programs to reduce exposure and accidents are described. The authors conclude that these aliphatic amines constitute a real health hazard to workers at current exposure concentrations.
NIOSH, Franklin Research Center, Silver Spring, 246 pages, 300 references