Styrene: development of a biologic standard for the industrial worker by breath analysis.
Hake-CL; Stewart-RD; Wu-A; Graff-SA; Forster-HV; Keeler-W; Lebrun-AJ; Newton-PE; Soto-RJ
NIOSH 1977 Jan; :142 pages
Monitoring techniques for styrene (100425) inhalation exposures were evaluated. Eighteen subjects were exposed to styrene vapor concentrations from 20 to 125 parts per million (ppm) from 1 to 7.5 hours per day for 1 week. Alveolar breath samples were taken 15 minutes after exposure. Blood styrene concentration and urinary metabolites were measured. An unexplained increase in basophils in subjects exposed to 125ppm of styrene. Blood styrene and urinary metabolite concentrations were limited in value for determining styrene exposure due to their large variability and the difficulty in obtaining and analyzing the samples. Alveolar breath samples provided an excellent measure of styrene exposure. The authors suggest that an alveolar value greater than 2.8ppm indicates an accumulated body burden of styrene that could be injurious to the health of the worker.
NIOSH-Contract; Contract-099-72-0084; Plastics; Polymers; Humans; Health-surveys; Hematology; Urinalysis; Occupational-medicine; Medical-monitoring
Final Contract Report
NTIS Accession No.
National Institute for Occupational Safety and Health
The Medical College of Wisconsin, Department of Environmental Medicine