Maternal lead exposure inhibits intestinal calcium absorption in rat pups.
Toraason-MA; Barbe-JS; Knecht-EA
Toxicol Appl Pharmacol 1981 Aug; 60(1):62-65
The effect of maternal lead (7439921) exposure on the development of duodenal calcium (7440702) absorption in rat pups was investigated. Female Sprague-Dawley-rats were fed a diet containing 0.5 percent lead-acetate (301042) for 5 weeks prior to breeding, during gestation, and through day 17 of lactation. Exposure to 0.5 percent lead-acetate diet produced blood lead concentration in the females of between 69 and 84 micrograms per 100 milliliters. The body weights of pups were significantly reduced on days 7 and 16, with the blood lead concentration in pups reaching a maximum on day 16 of lactation. Upon weaning blood lead concentrations declined, and reached a low of 7 micrograms per 100 milliliters by day 30. Calcium absorption on day 20 for lead exposed rats was significantly lower than control values, while by day 30 experimental and control pups showed similar values. The authors suggest that the presence of lead affects some aspect of calcium transport than is enhanced during maturation.
NIOSH-Author; Heavy-metals; Laboratory-animals; Reproductive-effects; Biological-transport; Transport-mechanisms; Alkaline-earth-metals; Gastrointestinal-system; Toxicology
7439-92-1; 7440-70-2; 301-04-2
Toxicology and Applied Pharmacology