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Health hazard alert: benzidine-, o-tolidine, and o-dianisidine- based dyes.
Rockville, MD: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 81-106, 1980 Dec; :1-36
Studies on the carcinogenicity and metabolism of benzidine (92875), o-tolidine (119937), and o-dianisidine (119904) based dyes are reviewed. Results of animal and human experiments are summarized. The authors conclude that exposure of workers to benzidine based dyes should be discontinued or reduced to the lowest possible concentrations. Exposure to o-tolidine and o-dianisidine based dyes should be limited. Recommendations to reduce worker exposure to these dyes include substituting less toxic dyes, establishing engineering controls for these chemicals, ensuring good housekeeping procedures and industrial hygiene practices, establishing restricted areas, informing employees of the adverse health effects of working with these dyes, placing employees with occupational exposure to these dyes under a medical monitoring program, providing facilities to remove residual chemicals, and monitoring employee exposures.
NIOSH-Author; Aromatic-hydrocarbons; Dyes; Animal-studies; Humans; Medical-research; Worker-health; Safety-engineering
92-87-5; 119-93-7; 119-90-4
Numbered Publication; Alert
NTIS Accession No.
DHHS (NIOSH) Publication No. 81-106
National Institute for Occupational Safety and Health
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division