Trichloroethylene "Blush": Dermal Response to Trichloroethylene and Ethanol.
Stewart-RD; Hake-CL; Peterson-JE
NIOSH 1973 May:19 pages
A dermal response occurring after combined exposure to ethanol (64175) and trichloroethylene (79016) (TCE) was investigated. Volunteers were exposed for 7.5 hours daily for 5 days to 200 parts per million (ppm) of TCE vapor, and were given an alcoholic beverage 2.5, 5.5, or 71.0 hours after exposure began. Blood and expired air samples were collected for TCE analysis. Dermal responses were observed visually. In subjects who consumed alcohol during TCE exposure, small red blotches appeared on their faces within 30 minutes after drinking started. The lesions became enlarged within 1.25 hours and spread over the entire face and part of the neck. Lines of demarcation between affected and unaffected areas were clear. The lesions gradually faded within 1 hour after peak intensity. Examination of the skin revealed that the red coloration was due to dilation of small vessels in the superficial skin. Onset of TCE blush was not accompanied by any other clinical symptoms. The skin response could still be elicited by alcohol challenge 71 hours after the last TCE exposure. The authors conclude that repeated TCE exposure and ingestion of an alcoholic beverage are necessary to elicit this dermal response.
NIOSH-Contract; Contract-099-72-0082; Alcohols; Organic-solvents; Skin-disorders;
NTIS Accession No.
Department of Environmental Medicine, The Medical College of Wisconsin, Milwaukee, Wisconsin