Chronic Inhalation Exposure of Rats, Rabbits, and Monkeys to 1,2,4- Trichlorobenzene.
Coate-WB; Schoenfisch-WH; Busey-WM; Lewis-TR
The toxic effects of chronic inhalation exposure to 1,2,4- trichlorobenzene (120821) (TCB) were investigated. Charles-River- rats, New-Zealand-White-rabbits, and cynomolgus-monkeys were exposed for up to 26 weeks to 25, 50, or 100 parts per million of TCB. Body weights and hematologic and serum biochemistry were tested in each species, pulmonary function and operant behavior were tested in monkeys, and ophthalmologic tests were performed in rabbits and monkeys. All animals were autopsied after exposure. The only exposure related changes were increases in the size of hepatocytes and degeneration of the inner zone of the renal cortex in rats after 4 or 13 weeks of exposure. The authors recommend reevaluation of the maximum allowable TCB concentration, and additional short term, low dose studies with other species.
NIOSH-Contract; Contract-099-73-0083; Laboratory-animals; Comparative-toxicology; Exposure-limits; Biological-effects; Cellular-reactions;
NTIS Accession No.
Hazleton Laboratories, Vienna, Virginia, Experimental Pathology Laboratories, Herndon, Virginia, and NIOSH, Cincinnati, Ohio