NIOSHTIC-2 Publications Search

Bioassay of coke oven coal tar carcinogenic activity, final report.

Authors
Bingham-E
Source
NIOSH :1-9
Link
NIOSHTIC No.
00118719
Abstract
The carcinogenicity of coke oven coal tar was investigated. C3H-mice were treated dermally twice a week with 50 milligrams of various benzo(a)pyrene (50328) (BaP) solutions in toluene, whole coal tar containing different amounts of BaP, the light oil coal tar fraction, or coal tar with the light oil removed. The mice were examined periodically for tumors and skin lesions, and were killed for autopsy when carcinoma was diagnosed. The carcinogenicity of whole coal tar with 0.6 percent BaP and the light oil fraction removed was greater than that of a 0.6 percent BaP solution in toluene. The potency of the BaP solution accounted for 71 percent of the carcinogenic activity of the tar in the absence of the light oil fraction and for 77 percent of the activity when the light oil fraction was present. Dilution of BaP solutions with toluene reduced the potency of the compound more than similar dilution of coal tar solutions. Threshold BaP doses for animals given BaP in toluene and those given coal tar were 0.0006 and 0.00006 milligram, respectively. The authors suggest that coal tar contains additional carcinogens whose potency is masked in the presence of high BaP concentrations or that act as carcinogens.
Keywords
NIOSH-Contract; Contract-099-73-0055; Laboratory-animals; Hydrocarbons; Polynuclear-hydrocarbons; Carcinogens; Carcinogenesis; Toxicology
CAS No.
50-32-8
Document Type
Final Contract Report
Funding Type
Contract
NTIS Accession No.
PB82-230236
NTIS Price
A02
Identifying No.
Contract-099-73-0055
Source Name
Contract-099-73-0055, NIOSH
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division