Aflatoxin inhibition of viral interferon induction.
Hahon N; Booth JA; Stewart JD
Antimicrob Agents Chemother 1979 Sep; 16(3):277-282
The inhibitory effect of aflatoxin on interferon induction by influenza was investigated. Rhesus-monkey cells from the LLC-MK2 line were exposed to 1 to 100 micrograms of aflatoxin-B1 (1162658), aflatoxin-G1 (1165395), aflatoxin-B2 (7220817), or aflatoxin-G2 (7241987), plus 1 milliliter of influenza virus. Interferon induction was determined. Interferon induction was inhibited by all four aflatoxins in the following order of decreasing potency: B1, G1, B2, G2. Aflatoxin-B1 caused the greatest decreases in cell growth and viability in confluent cultures. Cells treated with aflatoxin induced greater influenza virus growth than did normal cells. Aflatoxin did not alter the ability of interferon to aid in the cellular resistance against viral infection, and did not affect viral infectivity or replication. The authors conclude that the inhibition of interferon induction by aflatoxin may be responsible for decreasing resistance to viral infections.
NIOSH-Author; Toxins; Mammalian-cells; Infectious-diseases; Viral-diseases; Cellular-reactions
Nicholas Hahon, Appalachian Laboratory for Occupational Safety and Health' and Department of Pediatrics, West Virginia University, School of Medicine,2 Morgantown, West Virginia 26505
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Antimicrobial Agents and Chemotherapy