Tissue distribution and excretion of 14C-styrene in male and female rats.
Res Commun Chem Pathol Pharmacol 1979 Jun; 24(3):515-524
The tissue distribution and excretion of styrene (100425) and its metabolites in the rat at various time intervals after oral administration was investigated. Charles-River-CD-rats received an oral 20 milligram per kilogram dose of carbon-14 labelled styrene and were killed at intervals ranging from 2 to 72 hours postadministration. Samples of tissues, organs, and body fluids were prepared for quantitation of radioactivity. Styrene was well absorbed from the gastrointestinal tract. Less than 10 percent of the administered dose was found in the stomach, small intestine, and large intestine 8 hours after treatment. Excretion of styrene in the urine was rapid with more than 60 percent of the dose appearing in the urine within 8 hours of administration; by 24 hours urinary excretion accounted for 90 percent of the administered dose. Fecal excretion accounted for less than 2 percent of the dose. Peak tissue concentrations occurred at or before 4 hours after administration. The organ with the highest levels of radioactivity at all time intervals was the kidney, followed in decreasing order by the liver and pancreas. Concentrations in all tissues and organs were below 1 microgram per gram or milliliter at 24 hours. The authors conclude that there is a relationship between tissue distribution of styrene and kidney and liver toxicity.
NIOSH-Author; Plastics; Monomers; Body-distribution; Metabolites; Laboratory-animals; Gastrointestinal-system; Liver-disorders
Research Communications in Chemical Pathology and Pharmacology