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The effect of dietary disulfiram upon the tissue distribution and excretion of 14C-1,2-dibromoethane in the rat.

Authors
Plotnick-HB; Weigel-WW; Richards-DE; Cheever-KL
Source
Res Commun Chem Pathol Pharmacol 1979 Dec; 26(3):535-545
Link
NIOSHTIC No.
00117472
Abstract
The influence of dietary disulfiram (97778) upon the tissue distribution and excretion of orally administered 1,2-dibromoethane (106934) was investigated. Male Sprague-Dawley-rats were given 0.05 percent disulfiram in their food for 12 days. Animals were then given single 4 gram per kilogram doses of carbon-14 labeled 1,2- dibromoethane. At 24 and 48 hours after treatment, the rats were sacrificed and tissue distribution of 1,2-dibromoethane was determined. Tissue radioactivity levels were significantly greater in the liver, kidneys, spleen, testes, and brain of the rats receiving disulfiram than in comparisons receiving no pretreatment. The rate of clearance of radioactivity was appreciably lower in the disulfiram group, especially for clearance from the testes. Radioactivity levels in liver nuclei obtained from the disulfiram treated animals were significantly greater than in the comparisons. The authors suggest that nuclear uptake of 1,2-dibromoethane in disulfiram treated animals is related to the development of liver tumors.
Keywords
NIOSH-Author; Body-distribution; Laboratory-animals; Liver-cancer; Carcinogenesis; Dithiocarbamate-fungicides
CODEN
RCOCB8
CAS No.
97-77-8; 106-93-4
Publication Date
19791201
Document Type
Journal Article
Fiscal Year
1980
Issue of Publication
3
ISSN
0034-5164
Source Name
Research Communications in Chemical Pathology and Pharmacology
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