Teratologic assessment of butylene oxide, styrene oxide and methyl bromide.
Sikov-MR; Cannon-WC; Carr-DB; Miller-RA; Montgomery-LF; Phelps-DW
NIOSH 1981 Jul; :1-76
The teratogenicity of butylene-oxide (26249207), styrene-oxide (96093), and methylene-bromide (74953) was investigated. Pregnant Wistar-rats and New-Zealand-White-rabbits were exposed daily by inhalation to various low or high doses of the agents until gestation, day 21 for rats and 30 for rabbits; for some of the rats, exposures were started 3 weeks before mating. Fetuses were removed for examination after the final exposure. Butylene-oxide and methyl- bromide were not toxic to rats, but butylene-oxide and the high methylene-bromide doses were toxic to rabbits. Styrene-oxide was maternotoxic to both species. Teratogenic effects were seen only in rabbit or rat fetuses exposed to styrene-oxide. Preimplantation loss occurred in rats and resorptions were noted in rabbits. Fetal weight and length were reduced in both species. Rat fetuses also had ossification defects of the sternebrae and occipital bones. The authors conclude that styrene-oxide produces reproductive and developmental abnormalities. Methylene-bromide and butylene-oxide do not appear to be embryotoxic or teratogenic.
NIOSH-Author; Laboratory-animals; Comparative-toxicology; Teratogenesis; Reproductive-effects; Embryopathology; Congenital-effects
26249-20-7; 96-09-3; 74-95-3
NTIS Accession No.
DHHS (NIOSH) Publication No. 81-124