Cotton dust and complement in-vivo.
Olenchock-SA; Mull-JC; Boehlecke-BA; Major-PC
Chest 1981 Apr; 79(4)(Suppl):53-55
The relationship between cotton dust complement changes were studied in human subjects. Blood samples were taken from 22 subjects exposed to various concentrations of cotton dust. Blood samples were also taken from 28 nonexposed comparison subjects. Cotton samples were tested for endotoxin content. Forced expiration volume (FEV) of subjects was measured. Serum complement concentrations were measured along with serum hemolytic activity. Changes in serum complement were seen with decreased FEV after exposure to dust from Stoneville closed ball, bract intact (SCBB) cotton, but decreased FEV was not related to changes in serum complement after exposure to Stoneville closed ball, bract removed (SCB) or standard harvested cotton (SSC). Gram negative endotoxin activity was found in SCB, SCBB, and SSC cotton. The authors conclude that there are associations between cotton dust inhalation and serum complement mediated respiratory impairment, and these are independent of endotoxin contamination.
NIOSH-Author; Plant-dusts; Humans; In-vivo-studies; Dust-exposure; Pulmonary-function; Hematology; Pulmonary-system-disorders; Biochemical-analysis