Effect of dietary intake of lead acetate on copper metabolism in male rats.
Klauder-DS; Murthy-L; Petering-HG
Trace Subst Environ Health 1973 Jan; 6:131-136
The effect of lead (7439921) on copper (7440508) metabolism was investigated. Male Sprague-Dawley-rats were fed diets ranging in copper content from 0.5 to 2.5 micrograms per day. Fifty percent of the animals also received a diet containing 0.5 percent lead. During the 8 week experimental period, food and water intakes were periodically monitored and blood and urine samples were collected. Lead treated animals had growth retardation. There were negligible differences in food and water intakes. Lead inhibition was inversely related to dietary copper amounts. Lead treated animals had 15 to 20 times more lead in the urine than controls. Ceruloplasmin concentrations, a reliable measurement of copper metabolism, in lead exposed animals were markedly lower compared to controls. Erythrocyte lead concentrations decreased as the dietary copper increased. The authors conclude that one of the toxic effects of lead is to adversely change copper metabolism.
NIOSH-Publication; NIOSH-Grant; Stokinger; Toxicology; Heavy-metals; Metabolism; Laboratory-animals; Lead-compounds; Growth-factors
Environmental Health Kettering Laboratory Eden & Bethesda Avenues Cincinnati, Ohio 45219
Trace Substances in Environmental Health
University of Cincinnati, Cincinnati, Ohio