Toxicity Tests on Fluorescent Inks.
Division of Occupational Health, 1963 Jul:8 pages
The acute toxicity of zinc-silicate (13597654) and calcium-silicate (1344952) phosphors and two phosphorescent ink formulations was studied in humans and animals. Rabbit eye irritations, rat intragastaic feeding, guinea-pig skin sensitization, and human skin patch sensitization, and photosensitivity were tested. Rabbit eye irritation was read from 8 hours to 7 days after conjunctival exposure. Rat gross and histologic pathology were observed for 2 weeks after a 4 grams per kilogram intragastric dose. Male adult guinea-pig skin response was observed 4 days after a challenge exposure to topically sensitized animals. Human skin patch tests were monitored in 320 persons for 48 hours after a challenge exposure 2 weeks post sensitization. Human photosensitivity was measured in persons receiving topical doses followed by brief sunlight exposure. No positive reactions were observed in the rabbit eye irritation test. No gross or microscopic abnormalities, aside from some intestinal mucosal dye deposition, were recorded in the feeding test. Guinea-pig sensitization and human sensitization and phototoxicity tests were negative. The authors conclude that four substances are safe for their intended use as postal stamp inks. They recommend that periodic monitoring of the exposed postal worker population be conducted for at least a limited time.
Dyes; Coloring-materials; Humans; Animal-studies; Comparative-toxicology; Skin-exposure; Sensitivity-testing; Toxicology;
Division of Occupational Health, U.S. Department of Health Education, and Welfare, 8 pages, 7 references