Subclinical effects of chronic increased lead absorption - a prospective study 1. Study design and analysis of symptoms.
Spivey-GH; Brown-CP; Baloh-RW; Campion-DS; Valentine-JL; Massey-FJ; Browdy-BL; Culver-BD
J Occup Med 1979 Jun; 21(6):423-429
The subclinical effects of chronic lead (7439921) absorption in lead smelter workers (SIC-3341) was investigated. Subjects of the study included 70 workers who have had blood lead concentrations in the range of 60 to 80 micrograms per 100 milliliters for a minimum of 1 year, as reported by the company's medical surveillance records. The 35 workers in the control group were occupationally exposed to work conditions similar to those of the lead workers, except with no history of lead exposure. Baseline measurements of height, weight, and blood pressure were taken, and standard neurologic examinations, lead, arsenic, and cadmium blood measurements, oculomotor function tests, nerve conduction measurements, and audiological tests were performed on both worker cohorts. A questionnaire including a detailed symptom history, history of exposure to chemicals, and questions about work habits was also administered. Lead workers reported significantly more symptoms than control workers. Muscle and joint pain was reported by 65 percent of the lead workers and 45 percent of the control workers. There was no correlation between length of employment and number of reported symptoms. The authors conclude that questionnaire responses provide subjective evidence of central nervous system and musculoskeletal effects of lead absorption at blood lead concentrations lower than 80 micrograms per 100 milliliters.
JOCMA7; NIOSH-Publication; NIOSH-Grant; Musculoskeletal-system-disorders; Lead-poisoning; Lead-production; Lead-absorption; Hematology; Health-surveys; Worker-health; Metallic-poisoning
Reed Neurological Research Ctr University of California Reed Neurological Res Center Los Angeles, Calif 90024
Journal of Occupational Medicine
University of California Los Angeles, Los Angeles, California