Exposure to mixtures of airborne contaminants. Final progress report grant R01-OH-00472.
University of Rochester School of Medicine and Dentistry, Rochester, NY 1977 Apr; :1-25
The effect of particulate and gaseous airborne pollutants was studied in Camm-Harty-guinea-pigs. Animals were exposed for 6 hours per day, 5 days per week for 16 weeks to 1.2 milligrams per cubic meter (mg/cu m) of fluorspar (7789755) dust of respirable size, or to 3.3mg/cu m of hydrogen-fluoride (7664393) (HF). The animals were maintained for up to 89 days after exposure. Both agents caused increases in the fluoride burden in the plasma, femur and feces. Exposure to HF also increased the number of free alveolar macrophages, while the incidence of patchy pneumonitis decreased. Pulmonary edema persisted for 2 days after exposure. All responses returned to normal after exposure was terminated and no further adverse effects were seen. The author recommends that fluoride containing pollutants in the workplace be characterized and that epidemiological studies be performed for populations living near fluoride emitting industries.
NIOSH-Grant; Biochemistry; Physiology; Laboratory-animals; Air-contamination; Pulmonary-system-disorders
Radiation Biology & Biophysics University of Rochester Dept of Rad Biol & Biophysics Rochester, N Y 14642
Final Grant Report
University of Rochester School of Medicine and Dentistry, Rochester, NY
University of Rochester, Rochester, New York